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Synthesis of carbon-11 labeled methylcarbamates from [11C]-methylchloroformate

✍ Scribed by Hayden T. Ravert; William B. Mathews; John L. Musachio; Robert F. Dannals

Publisher
John Wiley and Sons
Year
1995
Tongue
French
Weight
386 KB
Volume
36
Category
Article
ISSN
0022-2135

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✦ Synopsis

1 1C]-Methylchloroformate, a novel [ 1 lcl-acylating agent, was generated in situ from [11C]-methanol and phosgene. To explore the utility of [11C]-methylchloroformate, this agent was reacted with several amines to yield their corresponding [I 1C]-labeled methylcarbamates. The average synthesis (including purification and formulation) required approximately 23 minutes from end of bombardment. The average specific activity was calculated to be approx. 607 mCi/pmole at end of synthesis with an average radiochemical yield of 6%, decay corrected to starting [I 1C]-methanol. Preliminary results reveal that [ I 1C]methylchloroformate is a useful general reagent for the preparation of [11C]-methyl carbamates of both primary and secondary amines.

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