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Synthesis of 11C-labelled choline

✍ Scribed by Mirko Diksic; Y. Lucas Yamamoto; William Feindel

Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
241 KB
Volume
21
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

We report the synthesis of ^11^C‐labelled choline using the reaction of “nocarrier‐added” ^11^C‐labelled methyliodide and 2‐amino‐(N,N‐dimethyl)‐ethanol. After determining the optimum temperature and duration for the reaction, we achieved a radiochemical yield of about 30% and the radioactivity levels needed for PET studies in humans.

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