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Enzymatic synthesis of 11C-labelled S-adenosylmethionine

✍ Scribed by Paul Gueguen; Jean-Louis Morgat; Mariannick Maziere; Gérard Berger; Dominique Comar; Michel Maman

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
480 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

This article describes the radiosynthesis of ^11^C‐labelled S‐adenosylmethionine by an enzymatic process. This methyl donor was prepared by condensation of L‐(methyl‐^11^C) methionine with ATP. The synthesis and purification could be carried out in 20 minutes with a final yield of 80 %. The specific radioactivity obtained was close to 200 Ci/mmole. 6 mCi of ^11^C‐labelled S‐adenosylmethionine was injected in a rabbit, and its repartition followed by an opticamera.

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