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Rapid catalytic synthesis of 11C-labelled aromatics

✍ Scribed by Maurizio Speranza; Richard A. Ferrieri; Alfred P. Wolf; Fulvio Cacace

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
421 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

^11^C‐Labelled benzene derivatives were prepared catalytically by trimerizing acetylene‐^11^C with acetylene and propyne carriers over 1.5 grams of silica‐alumina support activated by potassium chromate (0.2% by weight). Optimized yields of the ^11^C‐labelled aromatics were obtained when the reactants were exposed to the catalyst for 10 minutes at 24°C. A minimum addition of 50 μmole of alkyne carrier was necessary before the trimerization proceeded to give appreciable yields of ^11^C‐labelled aromatics. In the competitive trimerization of acetylene‐^11^C with acetylene and propyne carriers, three ^11^C‐labelled aromatic products were generated: benzene, toluene, and xylene. From these studies acetylene was observed to be 1.6 times more reactive than propyne. In addition, the observed distribution of ^11^C‐labelled xylenes (3.4% ortho, 10.6% meta, and 86% para) indicates an apparent regiospecificity in the trimerization of ^11^C‐acetylene with propyne.

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