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Rapid synthesis of 14C forskolin by a route suitable for 11C labeling

✍ Scribed by T. Sasaki; I Ogihara-Umeda; H. Nishigori; S. Ikegami; M. Senda; K. Kitani; K. Ogawa; T. Nozaki

Publisher
John Wiley and Sons
Year
1991
Tongue
French
Weight
400 KB
Volume
29
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Radiolabeled forskolin was synthesized by acetylation of deacetylforskolin with ^14^C‐labeled acetic acid in the presence of dicyclohexylcarbodiimide. Separation of labeled forskolin of greater than 97% radiochemical purity was achieved by HPLC with a reversed‐phase column. The synthesis and purification of labeled forskolin were achieved in less than 30 min and the radiochemical yield of labeled forskolin after HPLC purification was about 30%, These methods are therefore applicable for production of ^11^C‐forskolin which may be useful for PET second messenger imaging.

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