✦ LIBER ✦

Synthesis of tritium labelled choline analogs

✍ Scribed by Srinivasan Rajagopal; Mirko Diksic

Publisher: John Wiley and Sons
Year: 1991
Tongue: French
Weight: 290 KB
Volume: 29
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580290213

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✦ Synopsis

The synthesis of choline analogs S ( + ) and R(-) 2-hydroxy, 1-N,N,-dimethyl, N-[3H]methyl, propylammonium iodide, 3b, 3a; R(+) and S(-) 1-hydroxy, 2-N,N-dimethyl, N-["HI-methyl, propylarnmoniurn iodide, 6b. 6a; and N,N-dimethyl, N-13H]-methyl, propynylammonium iodide, S labelled with [3H] at the N-CH3 position was achieved with a radiochemical yield of 40% and specific activity of 9.3 Ci/rnmol. The preparation of desrnethyl compounds, enantiomeric and racemic 1,-N,N-dimethylamino 2-propanol &. 2b. 2ab; enantiomeric and racernic 2,-N,N-dimethylamino 1-propanol &, &, 5ab is also described.

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