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Synthesis of tritium-labelled isocarbacyclin derivatives, radiolabelled prostaglandin I 1 analogs(1)

✍ Scribed by Satoshi Sugiura; Seizi Kurozumi; Shiro Ikegami


Publisher
John Wiley and Sons
Year
1996
Tongue
French
Weight
395 KB
Volume
38
Category
Article
ISSN
0022-2135

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✦ Synopsis


Three tritiated isocarbacyclin [9 (0) -metano-A' methyl ester (7a), [11-3H] -(17s) -17-methyl-20-homoisocarbacyclin ( 9 ) , and its methyl ester (8a) were synthesized. Tritium was introduced to the 11-position via [3H] -sodium tetrahydroborate reduction of ll-dehydroisocarbacyclin intermediates 10 and 11. prostaglandin I11 derivatives, [ll-3 HI-isocarbacyclin