✦ LIBER ✦

Synthesis of tritium-labelled phosphonium choline

✍ Scribed by Edith Sim

Publisher: John Wiley and Sons
Year: 1984
Tongue: French
Weight: 216 KB
Volume: 21
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580210612

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✦ Synopsis

Tritium-labelled phosphonium choline chloride ( [2-hydroyyethyl ] trimethyl phosphonium chloride) has been synthesised using base-catalysed hydrogen exchangz of the hydrogen atoms attached to the carbon adjacent to the phosphonium phosphorus. Using H20 diluted in H 0, during the exchange reaction, it is 2 shown by proton-NMR that substitution of the methylene protons is almost complete when only 25% of the methyl protons have exchanged. Comparison of the measured specific activity (16.12mCi/mmol) with that calculated from the total proton exchange values shows that there is a large isotope effect favouring exchange to deuterium rather than tritium.

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