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Synthesis of tritium labelled zaleplon

✍ Scribed by V.P. Shevchenko; I.Yu. Nagaev; N.F. Myasoedov; A. Susan

Publisher: John Wiley and Sons
Year: 2002
Tongue: French
Weight: 73 KB
Volume: 45
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.612

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✦ Synopsis

Abstract

The reaction conditions for the incorporation of tritium into zaleplon have been investigated. The methods studied were the catalytic isotope exchange reaction with tritium gas and catalytic isotope exchange reaction with tritiated water. The results showed that the latter method was the method of choice giving a compound with a higher specific activity and a better yield. Copyright © 2002 John Wiley & Sons, Ltd.

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