## Abstract A method for the production of carboxy‐labelled l‐carnitine is described. The first step is the chemical synthesis of 4‐N‐trimethylammoniobutanoate (butyrobetaine) from the precursors 4‐aminobutanoate and iodomethane. The second step involves the hydroxylation of butyrobetaine to form l
Synthesis of carbon-11 labelled (R)-carnitine
✍ Scribed by M. Holschbach; W. Hamkens; W. Roden; L. E. Feinendegen
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- French
- Weight
- 261 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0022-2135
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✦ Synopsis
A route to 'lc-labelled (R) -carnithe (1) , based on the methylation of the dimethyl derivative ( 2 ) is described. Furthermore, a five-step synthesis for the enantiomerically pure precursor ( 2 ) is outlined. 0362 -4803/91/050599 -08W5.00 ' i j 1991 by John Wiley & Sons. Ltd.
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## Abstract A useful synthetic approach to carbon‐11 labelled 1,4‐dihydropyridines is described. Carbon‐11 labelled calcium channel antagonists ^11^C‐Nifedipine, ^11^C‐Nisoldipine, ^11^C‐Nitrendipine and ^11^C‐CF~3~‐Nifedipine were synthesized by a modified Hantzsch method using protected carboxy f
## Abstract Commercial (__l__)‐carnitine chloride was N‐demethylated by the action of sodium benzenemercaptide in warm N,N‐dimethylformamide. The product 4‐(N,N‐dimethylammonio)‐3‐hydroxybutanoic acid chloride salt was isolated in good yield by ion exchange chromatography. Methylation of the produc
1 1C]-Methylchloroformate, a novel [ 1 lcl-acylating agent, was generated in situ from [11C]-methanol and phosgene. To explore the utility of [11C]-methylchloroformate, this agent was reacted with several amines to yield their corresponding [I 1C]-labeled methylcarbamates. The average synthesis (inc