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Synthesis of radioactively methyl-labelled (l)-carnitine

✍ Scribed by Stephen T. Ingalls; Charles L. Hoppel; Julia S. Turkaly

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
295 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

Commercial (l)‐carnitine chloride was N‐demethylated by the action of sodium benzenemercaptide in warm N,N‐dimethylformamide. The product 4‐(N,N‐dimethylammonio)‐3‐hydroxybutanoic acid chloride salt was isolated in good yield by ion exchange chromatography. Methylation of the product by ^14^C ‐iodomethane in dry methanol produced biologically active 4‐N‐ Me‐^14^C ‐(l)‐carnitine chloride of high specific activity in excellent yield.

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