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Preparation of radioactive acetyl-l-carnitine by an enzymatic exchange reaction

✍ Scribed by R. Emaus; L.L. Bieber

Publisher: Elsevier Science
Year: 1982
Tongue: English
Weight: 417 KB
Volume: 119
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(82)90583-8

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✦ Synopsis

A rapid method for the preparation of [ I-'4C]acetyl-~-carnitine is described. The method involves exchange of [ I-'%]acetic acid into a pool of unlabeled acetyl-L-carnitine using the enzymes acetyl-CoA synthetase and carnitine acetyltransferase. After isotopic equilibrium is attained, radioactive acetylcarnitine is separated from the other reaction components by chromatography on Dowex 1 (Cl-) anion exchange resin. One of the procedures used to verify the product [ l-'4C]acetyl-~-carnitine can be used to synthesize (3.S)[5-'%]citric acid.

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