ChemInform Abstract: Preparation of Highly Functionalized Grignard Reagents by an Iodine—Magnesium Exchange Reaction and Its Application in Solid-Phase Synthesis.

Preparation of Highly Functionalized Gri

Preparation of Highly Functionalized Grignard Reagents by an Iodine–Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis

✍ Laure Boymond; Mario Rottländer; Gérard Cahiez; Paul Knochel 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB 👁 1 views

At -40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.