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Preparation of Highly Functionalized Grignard Reagents by an Iodine–Magnesium Exchange Reaction and its Application in Solid-Phase Synthesis

✍ Scribed by Laure Boymond; Mario Rottländer; Gérard Cahiez; Paul Knochel

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 107 KB
Volume: 37
Category: Article
ISSN: 0044-8249
DOI: 10.1002/(sici)1521-3773(19980703)37:12<1701::aid-anie1701>3.0.co;2-u

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✦ Synopsis

At -40°C aryl iodides that contain other functional groups can be selectively converted into Grignard reagents, which react with electrophiles such as benzaldehyde in the usual manner [Eq. (a)]. Aryl bromides and iodides that are immobilized as esters on a Wang resin behave analogously.

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## Abstract For Abstract see ChemInform Abstract in Full Text.