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Synthesis of carboxy-labelled l-carnitine

✍ Scribed by Donald B. Goodfellow; Charles L. Hoppel; Julia S. Turkaly

Publisher
John Wiley and Sons
Year
1982
Tongue
French
Weight
351 KB
Volume
19
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A method for the production of carboxy‐labelled l‐carnitine is described. The first step is the chemical synthesis of 4‐N‐trimethylammoniobutanoate (butyrobetaine) from the precursors 4‐aminobutanoate and iodomethane. The second step involves the hydroxylation of butyrobetaine to form l‐carnitine using butyrobetaine hydroxylase partially purified from bovine calf liver. The method also can be used to synthesize Me‐labelled and uniformly‐chain‐labelled l‐carnitine.

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