Asymmetric Synthesis of Protected γ-Carboxy-L-glutamic Acid.
✍ Scribed by Cedric Couturier; Melanie Liron; Thierry Schlama; Jieping Zhu
- Publisher
- John Wiley and Sons
- Year
- 2005
- Weight
- 24 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0931-7597
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📜 SIMILAR VOLUMES
l-[4-l3 C]Glutamic acid (1) and l-[4-13 C]glutamine (2) were synthesized from sodium [2-13 C]acetate (5) and Dellaria's oxazinone 3 as a chiral glycine equivalent. Sodium [2-13 C]acetate (5) was converted to [2-13 C]acrylate 4. Diastereoselective Michael addition of the enolate of 3 to the acrylate
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