## Abstract Optically pure (__R__)‐ and (__S__)‐3‐aminotetradeutero‐2‐thiophenone (D‐ and L‐[^2^H~4~]homocysteine thiolactone) for use as substrates for metabolic and pharmacokinetic studies has been prepared. The racemic [^2^H~4~]homocysteine thiolactone hydrochloride was prepared from commerciall
Synthesis of carbon-11 labelled D,L-homocysteine thiolactone
✍ Scribed by K. Hamacher; J. Hanus; G. Stöcklin
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- French
- Weight
- 83 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0022-2135
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📜 SIMILAR VOLUMES
L-[ 35S]Homocysteine thiolactone has been synthesized by demethylation of L-{ 35S]Methionine with sodium in liquid ammonia and subsequent lactonisation in acid solution. The radiochemical yield of the carrier added synthesis was in the range of 45 to 50 % with a radiochemical purity higher than 96 %
The synthesis of l-[llC]-D,L-homocysteine thiolactone, a potential tracer for PET imaging of ischemic heart regions, is described. The labelling is achieved by reaction o f [llC]carbon dioxide with 0-1 ithiated S-(tetrahydropyran-Z-y1)3-thiopropyl isonitri le. Deprotection o f the mercapto group and
A route to 'lc-labelled (R) -carnithe (1) , based on the methylation of the dimethyl derivative ( 2 ) is described. Furthermore, a five-step synthesis for the enantiomerically pure precursor ( 2 ) is outlined. 0362 -4803/91/050599 -08W5.00 ' i j 1991 by John Wiley & Sons. Ltd.
## Abstract A useful synthetic approach to carbon‐11 labelled 1,4‐dihydropyridines is described. Carbon‐11 labelled calcium channel antagonists ^11^C‐Nifedipine, ^11^C‐Nisoldipine, ^11^C‐Nitrendipine and ^11^C‐CF~3~‐Nifedipine were synthesized by a modified Hantzsch method using protected carboxy f
The suicide inhibitors of mnoamlne aridase type A and 8, clorgylina and L-deprenyl have been labeled with carbon-11 by [llC]methylation of the wrbases vlth [11C]E31. (D-deprenyl) wae dmo labeled uei-this procedure. The synthesis time was 35 minutes, the radiochemical yield was 2 5 4 0 % and the epec