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Synthesis of 1-[11C]-D,L-homocysteine thiolactone: A potential tracer for myocardial ischemia using PET

✍ Scribed by Kurt Hamacher; Jan Hanuš

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 424 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580271106

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✦ Synopsis

The synthesis of l-[llC]-D,L-homocysteine thiolactone, a potential tracer for PET imaging of ischemic heart regions, is described. The labelling is achieved by reaction o f [llC]carbon dioxide with 0-1 ithiated S-(tetrahydropyran-Z-y1)3-thiopropyl isonitri le. Deprotection o f the mercapto group and lactonisation o f the resulting thioamino acid is accomplished in an acid catalysed reaction. The radiochemical yield obtained is 10 to 15 % and the synthesis time, including the HPLC purification is about 45 min.

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