Radiosynthesis of (±)-1-(2-bromo-4,5-dimethoxybenzyl)-7-hydroxy-6-methoxy-2-[11C]-methyI-l,2,3,4-tetrahydro-isoquinoline, [11C]A-69024: A non-benzazepine antagonist for studying dopamine D1 receptors In vivo using PET

✍ Scribed by Michael Kassiou; William B. Mathews; John L. Musachio; Hayden T. Ravert; Richard M. Lambrecht; Robert F. Dannals

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: French
• Weight: 357 KB
• Volume: 34
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580340505

✦ Synopsis

Abstract

(±)‐1‐(2‐bromo‐4,5‐dimethoxybenzyl)‐7‐hydroxy‐6‐methoxy‐2‐[^11^C]‐methyl‐1,2,3,4‐tetrahydroisoquinoline, (HCJA‐69024, a selective ligand for the D1 receptor was prepared by N‐alkylation of (±)N‐desmethyl A‐69024 with [^11^C]methyl iodide in DMF. The radiotracer was purified by semi‐preparative reverse‐phase HPLC. The average specific activity was 1950 mCi/μmol calculated at end‐of‐synthesis (EOS). The average time of synthesis including formulation was 20 minutes.