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Synthesis of suicide inhibitors of monoamine oxidase: Carbon-11 labeled clorgyline, L-deprenyl and D-deprenyl

✍ Scribed by R. R. Macgregor; J. S. Fowler; A. P. Wolf; C. Halldin; B. Langström

Publisher
John Wiley and Sons
Year
1988
Tongue
French
Weight
336 KB
Volume
25
Category
Article
ISSN
0022-2135

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✦ Synopsis

The suicide inhibitors of mnoamlne aridase type A and 8, clorgylina and L-deprenyl have been labeled with carbon-11 by [llC]methylation of the wrbases vlth [11C]E31. (D-deprenyl) wae dmo labeled uei-this procedure. The synthesis time was 35 minutes, the radiochemical yield was 2 5 4 0 % and the epecific activity u a m 0.8-2.0 Ci/pml (calculated to EOB). Procedurw for rynthesis of the precursor wrbasee M we11 M the mynthesis of unlabeled clorgyline, L-deprenyl and D-daprenyl are given.

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## Preparation of Fluorinated Phenoxathiin Dioxide Monoamine Oxidase-A Inhibitors: Intramolecular Radical Substitution at Sulfur versus the Mauthner Synthesis. -The title compounds (VII) are prepared via a modification of the Mauthner synthesis which involves cyclization of thiophenols, e.g. (IV)