✦ LIBER ✦
ChemInform Abstract: Preparation of Fluorinated Phenoxathiin Dioxide Monoamine Oxidase-A Inhibitors: Intramolecular Radical Substitution at Sulfur versus the Mauthner Synthesis.
✍ Scribed by E. E. BOROS; W. R. HALL; M. HARFENIST; J. L. KELLEY; M. D. REEVES; V. L. STYLES
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 40 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0931-7597
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✦ Synopsis
Preparation of Fluorinated Phenoxathiin Dioxide Monoamine
Oxidase-A Inhibitors: Intramolecular Radical Substitution at Sulfur versus the Mauthner Synthesis.
-The title compounds (VII) are prepared via a modification of the Mauthner synthesis which involves cyclization of thiophenols, e.g. (IV), with halonitrobenzenes such as (V). An intramolecular radical substitution at sulfur of thiophenyl ethers (XI) is used for the preparation of the title compounds (XIII). Phenoxathiin (XIV) is formed via