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Synthesis of L-[35S]homocysteine thiolactone hydrochloride

✍ Scribed by Kurt Hamacher

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 156 KB
Volume: 27
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.2580270312

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✦ Synopsis

L-[ 35S]Homocysteine thiolactone has been synthesized by demethylation of L-{ 35S]Methionine with sodium in liquid ammonia and subsequent lactonisation in acid solution. The radiochemical yield of the carrier added synthesis was in the range of 45 to 50 % with a radiochemical purity higher than 96 %.

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