## Abstract Levofloxacin, the pure S enantiomer of the fluoroquinolone antibiotic ofloxacin, was labeled via methylation of the corresponding, __des__‐methyl, secondary amine with N.C.A. [^11^C]methyl iodide. The methylation reaction was regioselective, giving predominantly the preferred methyl ami
Synthesis of 11C-suriclone
✍ Scribed by C. Boullais; F. Oberdorfer; J. Sastre; C. Prenant; C. Crouzel
- Publisher
- John Wiley and Sons
- Year
- 1985
- Tongue
- French
- Weight
- 149 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
✦ Synopsis
llC-Suriclone
was synthetised i n a s h o r t time (30 minutes) with a h i g h s p e c i f i c a c t i v i t y (750 mCi/uMol) f o r s t u d i e s i n man w i t h t h e P o s i t r o n Emi.ssion Tomography technic. The s t a r t i n g m a t e r i a l was t h e N-demethylated product 35489 RP. The r a d i o a c t i v e reagent was e i t h e r llC-formaldehyde o r l1C-methyl i o d i d e .
📜 SIMILAR VOLUMES
## Abstract [^11^C]‐acetone, prepared from ^11^CO~2~ and methyllithium, was reduced to [^11^C]‐isopropanol. The latter reacted with methylphosphonic acid difluoride in the presence of diisopropylamine, to yield [11C]‐sarin. 3.4 GBq (100 mCi) of [^11^C]‐sarin may be obtained from about 55.5 GBq (1.
A method is described by which 100 mCi of pindolol may be obtained from about 1.5 Ci l1CO2 in 30 minutes. The product is chromatographically pure, sterile and apyrogenic with a specific activity between 600 and 1000 mCi/piuole at the time of use. The synthesis involves the preparation of lh-acetone
## Abstract A method for the preparation of sodium (^11^C]thiocyanate from [^11^C]cyanogen bromide and sodium sulfide is described. Sodium [^11^C]thiocyanate was obtained in 94% decay‐corrected radiochemical yield with a specific radioactivity of 122 GBq μmol^−1^ (3.3 Ci μmol^−1^) in a synthesis ti
## Abstract The synthesis of racemic [α‐^11^C]amphetamine and [α‐^11^C]‐phenethylamine from on‐line produced [^11^C]nitroethane and [^11^C]nitromethane, respectively, is described. The condensations of nocarrier‐added [^11^C]nitroalkanes with benzaldehyde to form [β‐^11^C]β‐nitrostyrenes were inves