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Synthesis of [11C]levofloxacin

โœ Scribed by M. S. Berridge; E. M. Burnazi

Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
78 KB
Volume
44
Category
Article
ISSN
0022-2135

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โœฆ Synopsis

Abstract

Levofloxacin, the pure S enantiomer of the fluoroquinolone antibiotic ofloxacin, was labeled via methylation of the corresponding, desโ€methyl, secondary amine with N.C.A. [^11^C]methyl iodide. The methylation reaction was regioselective, giving predominantly the preferred methyl amine at high temperature in DMF, while otherwise giving predominantly the methyl ester of a free carboxylic acid also present in the molecule. Levofloxacin was obtained in 80% chemical yield after a 45 min synthesis. Copyright ยฉ 2001 John Wiley & Sons, Ltd.

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