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Solid phase synthesis of protected peptide nucleic acids

✍ Scribed by Oliver Seitz

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 234 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00717-0

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✦ Synopsis

Boc/'Z-protected PNA oligomers were synthesised on solid phase. The use of the allylic HYCRON resin allowed for the application of both Boc-and Fmoc-protecting groups. Highest yields were obtained when the monomeric building block was synthesised on solid phase rather than loaded as preformed unit. The selective attachment of fluorescent labels at the C-terminal (3') end demonstrated for the fast time that further manipulations on protected PNA fragments are feasible.

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