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Solid phase synthesis of peptide hydroxamic acids

✍ Scribed by Jack J. Chen; Arno F. Spatola

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
225 KB
Volume
38
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of peptide hydroxamic acids has been performed on a solid support. A carboxyl group of a peptide synthesized on/xTa-methylbenzhydrylaminΒ’ (pMBHA) resin was converted to a hydroxamate functional group by condensing with NH2OBzl, which was found preferable to NH2OtBu or NH2OTrt. The hydroxama~ benzyl protecting group was removed subsequently during I-IF cleavage of the puptide resin. Five peptide hydroxamie acids wexe prepared according to this new method,

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