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Solid supported synthesis of hydroxamic acids

✍ Scribed by Adam Golebiowski; Sean Klopfenstein

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
185 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

A novel approach to the solid supported synthesis of hydroxamic acids was developed. It employs oxime resin and unlike all previously reported methods allows for the use of acid labile protecting groups. Cleavage is induced by treatment with tert-butyldimethylsilyl-O-hydroxylamine, followed by silyl group deprotection with trifluoroacetic acid.

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