✦ LIBER ✦

A TFA-cleavable linkage for solid-phase synthesis of hydroxamic acids

✍ Scribed by Lutz S. Richter; Manoj C. Desai

Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 116 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(96)02336-2

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✦ Synopsis

A novel linkage for the solid-phase synthesis of hydroxamic acids is described. The linkage is stable to all reagents commonly used in Fmoc peptide synthsis. Cleavage is induced by treatment with trifluoroacetie acid, providing hydroxamic acids in high purity and good yields.

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