๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

A facile and convenient solid-phase procedure for synthesizing nucleoside hydroxamic acids

โœ Scribed by Shoeb I. Khan; Mark W. Grinstaff

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
206 KB
Volume
39
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The solid-phase synthesis of a nucleoside hydroxamic acid is accomplished by the Pd(0) cross-coupling of 5-iodouridine and an O-linked hydroxylamine alkyne bound to 2chlorotrityl chloride polystyrene resin.

๐Ÿ“œ SIMILAR VOLUMES

N-Fmoc-aminooxy-2-chlorotrityl polystyre
N-Fmoc-aminooxy-2-chlorotrityl polystyrene resin: A facile solid-phase methodology for the synthesis of hydroxamic acids
โœ Sarah L Mellor; Carolann McGuire; Weng C Chan ๐Ÿ“‚ Article ๐Ÿ“… 1997 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 189 KB

Using the new compound N-Fmoe-hydroxylamine 1 we have generated a facile mute to a high loading, acid labile solid-phase resin bearing a hydroxylamine linker. The novel N-Fmoe-aminooxy-2chlorotrityl polystyrene 2 showed generic utility for the construction of hydroxamie acids, including peptidyl hyd