Automated solid phase synthesis of 2'-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)TT and d(Tp)3(CBZp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF.
A Short, Novel, and Cheaper Procedure for Oligonucleotide Synthesis Using Automated Solid Phase Synthesizer
โ Scribed by Quanlai Song; Zhiwei Wang; Yogesh S. Sanghvi
- Publisher
- John Wiley and Sons
- Year
- 2004
- Weight
- 71 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0931-7597
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