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A new deprotection strategy for automated oligonucleotide synthesis using a novel silyl-linked solid support

✍ Scribed by Anne Routledge; Mark P. Wallis; Kenneth C. Ross; William Fraser

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 291 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00368-4

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✦ Synopsis

Automated solid phase synthesis of 2'-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)TT and d(Tp)3(CBZp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF.

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