๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

N-Fmoc-aminooxy-2-chlorotrityl polystyrene resin: A facile solid-phase methodology for the synthesis of hydroxamic acids

โœ Scribed by Sarah L Mellor; Carolann McGuire; Weng C Chan

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
189 KB
Volume
38
Category
Article
ISSN
0040-4039

No coin nor oath required. For personal study only.

โœฆ Synopsis

Using the new compound N-Fmoe-hydroxylamine 1 we have generated a facile mute to a high loading, acid labile solid-phase resin bearing a hydroxylamine linker. The novel N-Fmoe-aminooxy-2chlorotrityl polystyrene 2 showed generic utility for the construction of hydroxamie acids, including peptidyl hydroxamicacids.

๐Ÿ“œ SIMILAR VOLUMES

N-Fmoc-dehydroalanine: a versatile molec
N-Fmoc-dehydroalanine: a versatile molecular scaffold for the rapid solid-phase synthesis of cycloaliphatic amino acids
โœ Brendan A Burkett; Christina L.L Chai ๐Ÿ“‚ Article ๐Ÿ“… 2000 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 141 KB

The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes aorded a range of conformationally constrained amino acids in moderate yields. The potential applications of this metho