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N-Fmoc-dehydroalanine: a versatile molecular scaffold for the rapid solid-phase synthesis of cycloaliphatic amino acids

✍ Scribed by Brendan A Burkett; Christina L.L Chai

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
141 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

The synthesis of polymer-supported N-Fmoc-dehydroalanine starting from S-protected cysteine via an oxidation/elimination strategy is described. Cycloaddition with a range of dienes aorded a range of conformationally constrained amino acids in moderate yields. The potential applications of this methodology to combinatorial libraries is discussed.

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