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Nucleic acid analog peptide (NAAP). Solid phase synthesis of a DNA analog peptide

โœ Scribed by Masayuki Fujii; Koji Yamamoto; Jinsai Hidaka; Takayuki Ohtsu

Publisher
Elsevier Science
Year
1997
Tongue
French
Weight
174 KB
Volume
38
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Solid phase synthesis of a nucleic acid analog peptide (NAAP), as a substitute for antisense or triple-helix forming oligonucleotide, is described. The N-protected amino acid monomer was prepared starting from 3'-azido-3'-deoxythymidine (AZT) in 20 % overall yield. Condensation of the amino acid monomer was performed using Boc-chemistry on MBHA resin to afford a decapeptide containing l0 thymine bases in 21% overall yield.

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