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Solid-Phase Synthesis of Peptide-Derived Enantiospecific Nucleic Acid Analogs

✍ Scribed by Vibhakar J. Shah; Robert Cerpa; Irwin D. Kuntz; Jr.; George L. Kenyon

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 207 KB
Volume: 24
Category: Article
ISSN: 0045-2068
DOI: 10.1006/bioo.1996.0018

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✦ Synopsis

The first solid-phase synthesis of novel peptide-derived enantiospecific nucleic acid analogs (PDNAs), employing all three stereoisomers of 4-(N 9 -adeninyl)-2-amino(t-boc)-butyric acid as ADNA (amino acid-derived nucleoside analogs) monomers has been described. The preliminary melting temperature (T m ) data obtained by hybridization experiments demonstrated that these PDNAs can anneal to their complementary nucleic acid strand dT 10 .

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