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Nucleic acid analog peptide (NAAP) 2. Syntheses and properties of novel DNA analog peptides containing nucleobase linked β-aminoalanine

✍ Scribed by Masayuki Fujii; Kohya Yoshida; Jinsai Hidaka; Takayuki Ohtsu

Publisher: Elsevier Science
Year: 1997
Tongue: English
Weight: 182 KB
Volume: 7
Category: Article
ISSN: 0960-894X
DOI: 10.1016/s0960-894x(97)00073-5

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✦ Synopsis

As substitutes for antisense and triplex oligonucleotides, oligopeptides containing N~-(thymin-l-ylacetyl) 13-aminoalanine and NO-(cytosin-l-ylacetyl) 13-aminoalanine moieties were synthesized on solid support by using standard Boc-chemistry.

The obtained peptide containing ten thymine bases was shown to form a hybrid duplex with a complementary oligo DNA, dA10 , with a melting temperature (Tm) of 36.5°C at pH 7,0,

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