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Solid phase synthesis of fully protected peptide alcohols

✍ Scribed by M. Mergler; F. Dick; J. Gosteli; R. Nyfeler

Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 158 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00829-1

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✦ Synopsis

A mild and efticient method to obtaia fully t-&tyl type protected alcohols based on the alkylation of Fmoc amino alcohols with the "polymeric dipheayldiazomethane" 1 followed by StanQrd Fmoc solid phase synthesis is presented. The resulting pepidyl benzhydryl ethers 3 can he cleaved with 1 -2% trlfluoroac&c acid in methylene chloride to yield the protected peptide alcohols.

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