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Solid-phase Synthesis of C-Terminal Peptide Amino Alcohols

✍ Scribed by Witold Neugebauer; Emanuel Escher

Publisher
John Wiley and Sons
Year
1989
Tongue
German
Weight
325 KB
Volume
72
Category
Article
ISSN
0018-019X

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✦ Synopsis

The solid-phase syntheses of enkephalin and somatostatin analogues with C-terminal OH functions instead of the normal carboxylates are described. The OH function of the N-terminal amino alcohol was acylated with succinic acid and esterified to the solid support. Normal Boc-TFA solid-phase strategy can be applied to build up and cleave these peptides. The succinic 'handle' can be removed by mild basic hydrolysis after cleavage.

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## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.