Fmoc-Compatible Solid-Phase Peptide Synthesis of Long C-Terminal Peptide Thioesters
โ Scribed by Axel Sewing; Donald Hilvert
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- English
- Weight
- 55 KB
- Volume
- 40
- Category
- Article
- ISSN
- 0044-8249
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
## Abstract Solidโphase synthesis of biomolecules, of which peptides are the principal example, is well established. However, synthetic peptides containing modifications at the carboxy termini are often desired because of their potential therapeutic properties. As a result, there is a necessity for
Established methodology for the preparation of peptide thioesters requires the use of t-butoxycarbonyl chemistry owing to the lability of thioester linkers to the nucleophilic reagents used in Fmoc solid phase peptide synthesis. Both the greater ease of use and the broad applicability of the method
## Abstract The mannose binding proteins on the surface of the dendritic cells are responsible for capture of pathogens in the early stages of immune response. Conjugation to mannose dendrimers is a rarely explored but potentially powerful strategy for enhancing immunogenicity of synthetic peptides