Conversion of NGurethane protected arginine to ornithine in peptide solid phase synthesis
โ Scribed by Hans Rink; Peter Sieber; Fritz Raschdorf
- Publisher
- Elsevier Science
- Year
- 1984
- Tongue
- French
- Weight
- 218 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0040-4039
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โฆ Synopsis
It is shown that Di-Adoc or Boc as guanidino protecting groups do not prevent theacylationand the subsequent conversion of arginine to ornithine in Fmoc solid phase peptide synthesis,
๐ SIMILAR VOLUMES
An efficient "one-pot" conversion of Fmoc-protected amino acids to the ureas in the solid phase is described. This methodology uses MeSiCI3 in the presence of Et3N to cleave Fmoc-protected amines directly to their isocyanates. This transformation has been demonstrated on some Fmocprotected amino aci
An efficient and direct conversion of Fmoc-protected dipeptides to hydantoins in the solid phase is described. This methodology uses MeSiCI3 in the presence of Et3N to cleave Fmoc-protected amines directly to their isocyanates. Internal cyclization of the amide on the isocyanate follows to produce t
A one-pot conversion of N-fluorenylmethoxycarbonyl (Fmoc) amino acids and dipeptides linked to Wang resin into the corresponding N-tert-butoxycarbonyl (Boc) derivatives was achieved in very high yields. The transformation was corroborated by cleaving of the Boc derivatives with trimethyltin hydroxid