✦ LIBER ✦

Transprotection in solid phase peptide synthesis: Easy conversion of Fmoc carbamates into Boc carbamates

✍ Scribed by Ricardo L.E. Furlán; Ernesto G. Mata

Publisher: Elsevier Science
Year: 1998
Tongue: French
Weight: 130 KB
Volume: 39
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(98)01350-1

No coin nor oath required. For personal study only.

✦ Synopsis

A one-pot conversion of N-fluorenylmethoxycarbonyl (Fmoc) amino acids and dipeptides linked to Wang resin into the corresponding N-tert-butoxycarbonyl (Boc) derivatives was achieved in very high yields. The transformation was corroborated by cleaving of the Boc derivatives with trimethyltin hydroxide.

📜 SIMILAR VOLUMES

ChemInform Abstract: Transprotection in

ChemInform Abstract: Transprotection in Solid Phase Peptide Synthesis: Easy Conversion of Fmoc Carbamates into Boc Carbamates.

✍ R. L. E. FURLAN; E. G. MATA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 23 KB 👁 2 views

Direct conversion of Fmoc-protected amin

Direct conversion of Fmoc-protected amines into O-alkyl carbamates by the Mitsunobu reaction: a practical strategy for the solid-phase synthesis of carbamates

✍ Florencio Zaragoza; Henrik Stephensen 📂 Article 📅 2000 🏛 Elsevier Science 🌐 French ⚖ 95 KB

Support-bound, Fmoc-protected amines react with aliphatic alcohols in the presence of ADDP, PBu 3 , and DIPEA to yield O-alkyl carbamates. The reaction presumably proceeds via O-alkylation of an intermediate carbamate anion.