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Direct conversion of Fmoc-protected amines into O-alkyl carbamates by the Mitsunobu reaction: a practical strategy for the solid-phase synthesis of carbamates

✍ Scribed by Florencio Zaragoza; Henrik Stephensen

Publisher: Elsevier Science
Year: 2000
Tongue: French
Weight: 95 KB
Volume: 41
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(00)00088-5

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✦ Synopsis

Support-bound, Fmoc-protected amines react with aliphatic alcohols in the presence of ADDP, PBu 3 , and DIPEA to yield O-alkyl carbamates. The reaction presumably proceeds via O-alkylation of an intermediate carbamate anion.