The solid-phase syntheses of enkephalin and somatostatin analogues with C-terminal OH functions instead of the normal carboxylates are described. The OH function of the N-terminal amino alcohol was acylated with succinic acid and esterified to the solid support. Normal Boc-TFA solid-phase strategy c
✦ LIBER ✦
Solid-phase synthesis of C-terminal peptide amides from N-tetrachlorophthaloyl protected amino acids
✍ Scribed by Esther Cros; Marta Planas; Xavier Mejı́as; Eduard Bardajı́
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 67 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
A new strategy for solid-phase synthesis of C-terminal peptide amides based on the use of N-tetrachlorophthaloyl protected amino acids with acid-labile side-chain protection is described.
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