Automated solid phase synthesis of 2'-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)TT and d(Tp)3(CBZp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF.
β¦ LIBER β¦
Solid Phase Synthesis of a Mitozolomide-oligonucleotide Conjugate Using a Novel Silyl-linked Solid Support
β Scribed by ANDREW J. WALSH; KENNETH C. ROSS; ANNE ROUTLEDGE; MARK P. WALLIS; WILLIAM FRASER
- Book ID
- 118109944
- Publisher
- Pharmaceutical Press
- Year
- 1996
- Tongue
- English
- Weight
- 538 KB
- Volume
- 2
- Category
- Article
- ISSN
- 2042-7158
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A convenient solid-phase synthesis of oligonucleotides conjugated at the 3Π-end with a tetraphenylporphyrin residue, by means of a new polymeric support bearing as a linker a lysine derivative, has been developed. A porphyrin linked