Automated solid phase synthesis of 2'-deoxyribose oligonucleotides; d(Tp)7T, d(Tps)TT and d(Tp)3(CBZp)2(Tp)2T, was achieved directly in 99% overall yields using a novel silyl linkage to a CPG silica support cleavable within seconds at room temperature using TBAF.
β¦ LIBER β¦
ChemInform Abstract: A New Deprotection Strategy for Automated Oligonucleotide Synthesis Using a Novel Silyl-Linked Solid Support.
β Scribed by A. ROUTLEDGE; M. P. WALLIS; K. C. ROSS; W. FRASER
- Book ID
- 112025191
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 24 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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