Three peptide-oligonucleotide phosphorothioate hybrids were synthesized using a new approach for stepwise solidphase synthesis of conjugates. This method utilizes commercially available N a -Fmoc amino acids for peptide synthesis and a new solid support. Three specific modifications of the solid-pha
A Convenient Solid-Phase Method for the Synthesis of Novel Oligonucleotide-Folate Conjugates
β Scribed by Stetsenko, Dmitry A.; Gottikh, Marina B.; Kazanova, Eugenia V.; Zubin, Eugeny M.; Kachalova, Anna V.; Volkov, Eugeny M.; Oretskaya, Tatiana S.
- Book ID
- 115492061
- Publisher
- Taylor and Francis Group
- Year
- 2007
- Tongue
- English
- Weight
- 188 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0732-8311
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A convenient solid-phase synthesis of oligonucleotides conjugated at the 3Π-end with a tetraphenylporphyrin residue, by means of a new polymeric support bearing as a linker a lysine derivative, has been developed. A porphyrin linked
Solid-phase synthesis of a folate tripyrrolocarboxamide conjugate 8 of a DNA binding polyamide is described. The synthesis of a new building block monomer Boc-Py-[(CH 2 ) 3 -NHFmoc] acid 3 is also reported.