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Towards a general method for the stepwise solid-phase synthesis of peptide–oligonucleotide conjugates

✍ Scribed by Maxim Antopolsky; Elena Azhayeva; Unni Tengvall; Alex Azhayev

Publisher
Elsevier Science
Year
2002
Tongue
French
Weight
74 KB
Volume
43
Category
Article
ISSN
0040-4039

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✦ Synopsis

Three peptide-oligonucleotide phosphorothioate hybrids were synthesized using a new approach for stepwise solidphase synthesis of conjugates. This method utilizes commercially available N a -Fmoc amino acids for peptide synthesis and a new solid support. Three specific modifications of the solid-phase were made after the peptide and before the oligonucleotide assembly.

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