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A general method for the solid phase synthesis of ureas

✍ Scribed by Steven M. Hutchins; Kevin T. Chapman

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
245 KB
Volume
35
Category
Article
ISSN
0040-4039

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✦ Synopsis

Abstrnctr A general method for the solid-phase synthesis of ureas has been developed. The key intermediate being a p-nitrophenylcarbamate which is transformed into the urea by reaction with primary or secondary amines. The products obtained are of high chemical purity.

The generation of molecular diversity has become a topic of much discussion.1 Peptide libraries have

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Three peptide-oligonucleotide phosphorothioate hybrids were synthesized using a new approach for stepwise solidphase synthesis of conjugates. This method utilizes commercially available N a -Fmoc amino acids for peptide synthesis and a new solid support. Three specific modifications of the solid-pha