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Stepwise solid-phase synthesis of peptide–oligonucleotide phosphorothioate conjugates employing Fmoc peptide chemistry

✍ Scribed by Maxim Antopolsky; Alex Azhayev

Publisher
Elsevier Science
Year
2000
Tongue
French
Weight
86 KB
Volume
41
Category
Article
ISSN
0040-4039

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✦ Synopsis

A straightforward stepwise method for the preparation of peptide-oligonucleotide phosphorothioate conjugates, was developed, based on the highly efficient Fmoc peptide solid phase synthesis, followed by oligonucleotide phosphorothiate chain assembly. The three conjugates synthesized contained 15-or 17-mer oligonucleotide phosphorothioates and 10-or 16-mer peptides, incorporating two or three arginine residues.

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