A straightforward stepwise method for the preparation of peptide-oligonucleotide phosphorothioate conjugates, was developed, based on the highly efficient Fmoc peptide solid phase synthesis, followed by oligonucleotide phosphorothiate chain assembly. The three conjugates synthesized contained 15-or
Racemization studies of Fmoc-Cys(Trt)-OH during stepwise Fmoc-Solid phase peptide synthesis
✍ Scribed by T Kaiser; G.J Nicholson; H.J Kohlbau; W Voelter
- Publisher
- Elsevier Science
- Year
- 1996
- Tongue
- French
- Weight
- 188 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0040-4039
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📜 SIMILAR VOLUMES
In order to minimise the formation of the pyrophosphate derivative of the target peptide when side-chainunprotected phopshotyrosine is used in solid-phase peptide synthesis, this building block can be incorporated using benzotriazolyloxy-tris-(dimethylamino)phosphonium hexafluorophosphate/1-hydroxyb
## Abstract The title compounds, **4** and **7**, have been prepared from the corresponding __α__‐amino acid derivative selenocystine (**1**) by the following sequence of steps: cleavage of the SeSe bond with NaBH~4~, __p__‐methoxybenzyl (PMB) protection of the SeH group, Fmoc or Boc protection at
## Abstract Fmoc‐__β__^2^hSer(^__t__^Bu)‐OH was converted to Fmoc‐__β__^2^hSec(PMB)‐OH in five steps. To avoid elimination of HSeR, the selenyl group was introduced in the second last step (Fmoc__‐β__^2^hSer(Ts)‐OAll→Fmoc‐__β__^2^hSec(PMB)‐OAll). In a similar way, the __N__‐Boc‐protected compound w